Abnormal striatal dopamine transmission in schizophrenia. May not be copied or archived without express, prior, written permission. Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Father: Gottfrid Carlsson (historian)Wife: Ulla-Lisa (until his death, three sons, two daughters)Son: BoSon: HansDaughter: LenaSon: Magnus (d. 2015)Daughter: Maria L Carlsson (neuropsychopharmacologist), Medical School: MD, University of Lund (1951) University: PhD, University of Lund (1951) Teacher: Pharmacology, University of Lund (1944-59) Scholar: Chemical Pharmacology, National Institutes of Health (1955-56) Professor: Pharmacology, University of Gothenburg (1959-89), Wolf Prize in Medicine 1979 Japan Prize 1994 Nobel Prize for Medicine 2000 (with Paul Greengard and Eric R. Kandel) National Academy of Sciences Swedish Ancestry, Author of books: Neurocognitive endophenotypes in schizophrenia: modulation by nicotinic receptor systems. Functional and anatomical aspects of prefrontal pathology in schizophrenia. Braff DL, Geyer MA. 139. Goldman-Rakic PS, Castner SA, Svensson TH, Siever LJ, Williams GV. (178, 179), review by Mackowick et al. Improving cognition in schizophrenia with antipsychotics that elicit neurogenesis through 5-HT 1A receptor activation. (160) attributes the disturbed function of astrocytes in schizophrenia to diminished glutamate metabolism. Gross G, Wicke K, Drescher KU. Keywords: Mackowick KM, Barr MS, Wing VC, Rabin RA, Ouellet-Plamondon C, George TP. Carlsson A, Carlsson ML.
Wang YC, Ho UC, Ko MC, Liao CC, Lee LJ. COMT influences on prefrontal and striatal blood oxygenation level-dependent responses during working memory among individuals with schizophrenia, their siblings, and healthy controls. Antipsychotic drugs block D (2) receptors and increase the release of glutamate in the striatum (109), particularly on the right side of the striatum, which is a brain region involved in cognition and reward motivation (110). Click for More Info on Volume 1, Volume 2, Volume 3, Volume 4, and Volume 5 (including the complete name lists in each volume). Bortz DM, Mikkelesen JD, Bruno JP. doi:10.1016/j.biopsych.2008.01.010, 107. Meincke U, Mörth D, Voss D, Thelen B, Geyer MA, Gouzoulis-Mayfrank E. Prepulse inhibition of the acoustically evoked startle reflex in patients with an acute schizophrenic psychosis-A longitudinal study. Fue profesor emérito de esa universidad hasta su muerte. Seeman P, Guan H-C. Dopamine partial agonist action of (-)OSU6162 is consistent with dopamine hyperactivity in psychosis. Adenosine interacts with glutamate, NMDA-receptors, and dopamine [review by Burnstock et al.
Evaluation of the antipsychotic effect of bi-acetylated L-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligand. D (1) receptors in the prefrontal cortex are decreased in schizophrenia patients and are unaffected by chronic treatment of typical neuroleptics [review by Friedmann et al. Lodge DJ, Grace AA. Furthermore, dopaminergic and serotonergic deviations are known to contribute significantly to both the positive and negative symptoms of schizophrenia [review by Davis et al. 72. Scarr E, Gibbons AS, Neo J, Udawela M, Dean B. Cholinergic connectivity: it’s implications for psychiatric disorders. Schizophr Res (1997) 28:157–62. Drawing on that research, Hornykiewicz and his assistant, Herbert Ehringer, discovered in 1960 that the brains of patients who had died of Parkinson’s had very low levels of dopamine. Kondziella D, Brenner E, Eyjolfsson EM, Markinhuhta KR, Carlsson ML, Sonnewald U. Glial-neuronal interactions are impaired in the schizophrenia model of repeated MK801 exposure.