Advertising revenue supports our not-for-profit mission. Clinical diagnostic criteria resulting from the multivariate analysis.
http://www.arthritis.org/about-arthritis/types/rheumatic-fever/. In our casuistry, a male preponderance was observed among patients with adult-onset PFAPA syndrome, while the number of females was higher in the control group. Impact Factor 5.085 | CiteScore 5.4More on impact ›, Autoinflammatory Diseases: From Genes To Bedside
Both patients with adult-onset PFAPA syndrome and subjects belonging to the control group experienced a disease onset over the age of 16. Rheumatic heart disease in the modern era: Recent developments and current challenges. In some cases, the inflammation causes long-term complications. Cantarini L, Vitale A, Bartolomei B, Galeazzi M, Rigante D. Diagnosis of PFAPA syndrome applied to a cohort of 17 adults with unexplained recurrent fevers. Yamaguchi M, Ohta A, Tsunematsu T, Kasukawa R, Mizushima Y, Kashiwagi H, et al. Failure to comply may result in legal action.
Am J Med (1967) 43:227–53. The following are common causes of fever: Your healthcare provider will ask when your fever began and how high it was. Therefore, we analyzed the occurrence of inflammatory features in patients with a clinical picture consistent with adult-onset PFAPA syndrome, being excluded all the known causes of recurrent fever, as well as in patients consecutively visited in our Units because of FUO during a 6-month period. Group A streptococcus infections of the skin or other parts of the body rarely trigger rheumatic fever. Kolly L, Busso N, von Scheven-Gete A, Bagnoud N, Moix I, Holzinger D, et al.
doi:10.1007/s10067-016-3317-7, 11. Steer A, et al. doi:10.1080/1744666X.2017.1280396, 28. View all
As reported in Table 3, according to multivariate analysis performed on the two groups of patients, clinical variables that showed a statistical significant (p < 0.05) discriminant power to identify PFAPA patients were: recurrent fever accompanied by cervical lymphadenitis (OR = 92), recurrent fever with concomitant erythematous pharyngitis (OR = 231), increased inflammatory markers during attacks (OR = 588), and symptom-free intervals corresponding to the lack of clinical manifestations and laboratory abnormalities between flares (OR = 1,202). LOO uses all available data to train and test model: it executes a number of training sessions equal to the sample size (N) and in each of them it classifies each patient (LOO testing case) in turn by using all other patients as training set.
Acute rheumatic fever: Treatment and prevention. doi:10.1002/art.39961, 41. Cardiac involvement during acute rheumatic fever can result in rheumatic heart disease, which can cause heart failure and premature mortality. In addition to fever (often achieving and overcoming 40°C), aphthous stomatitis, pharyngitis, and cervical adenitis, many other clinical manifestations may enrich the clinical framework of PFAPA patients, including abdominal pain, headache, nausea, skin manifestations, and arthralgia (1, 8–10).
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He or she will ask about other symptoms and examine you for signs of infection. doi:10.1007/s10067-015-2890-5. In both cases, the patients showed the resolution of fever and of cardinal symptoms as well as the normalization of acute phase reactants. International periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome cohort: description of distinct phenotypes in 301 patients. Cazzato M, Neri R, Possemato N, Puccini R, Bombardieri S. A case of adult periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome associated with endocapillary proliferative glomerulonephritis. https://www.uptodate.com/contents/search.
Table 4. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products.
LCa and AV designed the study; LCa and RM finally revised the manuscript; LCa, RM, AV, GE, DR, LLS, GE, EV, IP, LCe, CF, BF, and MG final approval of the manuscript; LCa, AV, and DR drafting of the manuscript; GC and AV data analysis; LLS, GE, EV, IP, LCe, CF, BF, and MG patients enrollment, follow-up of the patients, and data collection. doi:10.1016/j.autrev.2012.07.021, 20. 10. Lancet (1990) 335:1078–80. *Correspondence: Luca Cantarini, cantariniluca@hotmail.com, Front. Our diagnostic criteria have been tested on adult patients and should be applied only to subjects aged at least 16 years.
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